Leeds return to Elland Road on Saturday for yet another Yorkshire derby, this time against Sheffield United.
New loan signing George McCartney is expected to go straight into the Leeds squad and could start with Federico Bessone still injured.
Grayson made a number of changes for last weeks game with Doncaster and he must decide whether to recall some of the players that were rested.
Paul Connolly missed the Doncaster game with a hamstring injury and will still be missing for this one.
Billy Paynter has had a setback in his recovery after playing in a behind closed doors friendly last week and remains on the sidelines.
Ross McCormack started his first game for the club but was replaced half way through the second half with an ankle injury.
Robert Snodgrass and Amdy Faye both came through 90 minutes for the reserves in midweek and will be pushing for inclusion.
Honduran international Ramon Nunez has finally received international clearance and could be added to the squad.
Adam Clayton will be missing after being sent off in the midweek reserve draw with Middlesbrough.
Also still missing are Kasper Schmeichel, Ben Parker and Patrick Kisnorbo with longer-term injuries.
Sheffield United welcome former England goalkeeper Richard Wright into the squad after he signed in midweek.
The Blades will be without club captain Chris Morgan with a hamstring injury.
Striker Daniel Bogdanovic who claimed Leeds were chasing him during the summer, could make his first start for the Blades after coming through a reserve game in midweek.
Stephen Quinn and Mark Yeates are both pushing for recalls to the starting eleven.
The game will see a familiar face return to Elland Road with Sheffield United.
Gary Speed started his career at Leeds is now the manager of Sheffield United and will be hoping to get one over on his former teammate Simon Grayson.
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